The journal Industrial & Engineering Chemistry Research is publishing a collection of papers honoring Professor José Luis García Fierro of Institute of Catalysis and Petrochemistry, CSIC (Spain) to recognize his contributions to applied chemistry, mainly in catalysis.
We have had the honour to participate in this issue with a work that describes a fast, simple, and easily scalable process for polyglucosylation of the flavonoid rutin. This can be used as a strategy to enhance its aqueous solubility and bioavailability. We isolated and chemically characterized six glucosides. The addition of amyloglucosidase STA1 allowed us to increase the monoglucoside yield up to 2-fold. Glucosylated derivatives of rutin also possess a great potential to improve the dissolution and absorption of poorly water-soluble pharmaceuticals.
“Polyglucosylation of rutin catalyzed by cyclodextrin glucanotransferase from Geobacillus sp.: Optimization and chemical characterization of products”. J.L. González-Alfonso, A. Poveda, M. Arribas, Y. Hirose, M. Fernández-Lobato, A.O. Ballesteros, J. Jiménez-Barbero & F.J. Plou. Industrial and Engineering Chemistry Research (2021). https://doi.org/10.1021/acs.iecr.1c03070