1 Apr 2024

Publication in Biocatalysis and Biotransformation: acylation of the flavonoid puerarin

This study was performed in collaboration with CIATEJ (Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A.C, Guadalajara, Jal, Mexico). The objective was to investigate the transesterification of isoflavones puerarin and its fructosylated derivative to enhance their lipophilicity for specific pharmacological applications. The process achieved high yields (80-100%) in the isoflavones conversion when lipases from Candida antarctica (CALB) and Thermomyces lanuginosus (TL IM) were used. The acyl derivatives presented improved lipophilicity and antioxidant activity.

Ref: A. Campos; L. Casas-Godoy; J.-G. Torres-Tolentino; G. Sandoval; L. Hernández; F. Plou; J. Arrizon. Lipase-catalyzed synthesis of laurate esters from puerarin and its β-D-fructofuranosyl-(2→6)-puerarin derivative.  Biocatalysis and Biotransformation (2024), https://doi.org/10.1080/10242422.2024.2332294